A Dimeric Bis(melamine)‐Substituted Bispidine for Efficient Transmembrane H+/Cl− Cotransport. (9th March 2017)

• Record Type: Journal Article
• Authors: Shinde, Sopan Valiba; Talukdar, Pinaki
• Is Part Of: Angewandte Chemie. Volume 129:Number 15(2017)
• Page Start: 4302
• Page End: 4306
• Publication Date: 2017-03-09
• Subjects: Kooperativität -- Ionentransport -- pH-abhängige Aktivität -- Protonierung -- Symportmechanismus; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201700803
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: A 3, 7‐diazabicyclo[3.3.1]nonane linking to two melamines is a unique transmembrane H + /Cl − carrier. In the solid state, the V‐shaped compound forms a HCl‐bound zig‐zag network through cooperative protonation and hydrogen bond interactions. In the lipid membrane, the receptor forms a dimeric self‐assembly involving multiple H + and Cl − leading to the efficient transport of the acid. The pH‐dependent Cl − efflux observed for the compound was rationalized based on a gradual protonation model that confers an active transmembrane carrier at physiological pH.