Regimes of Biomolecular Ultrasmall Nanoparticle Interactions. (15th March 2017)

• Record Type: Journal Article
• Authors: Boselli, Luca; Polo, Ester; Castagnola, Valentina; Dawson, Kenneth A.
• Is Part Of: Angewandte Chemie. Volume 129:Number 15(2017)
• Page Start: 4279
• Page End: 4282
• Publication Date: 2017-03-15
• Subjects: Bioanorganische Chemie -- Elektrophorese -- Nanopartikel -- Proteine -- Proteomik; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201700343
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Ultrasmall nanoparticles (USNPs), usually defined as NPs with core in the size range 1–3 nm, are a class of nanomaterials which show unique physicochemical properties, often different from larger NPs of the same material. Moreover, there are also indications that USNPs might have distinct properties in their biological interactions. For example, recent in vivo experiments suggest that some USNPs escape the liver, spleen, and kidney, in contrast to larger NPs that are strongly accumulated in the liver. Here, we present a simple approach to study the biomolecular interactions at the USNPs bio‐nanointerface, opening up the possibility to systematically link these observations to microscopic molecular principles.