Therapeutics of postpartum depression. (4th May 2017)

• Record Type: Journal Article
• Authors: Thomson, Michael; Sharma, Verinder
• Is Part Of: Expert review of neurotherapeutics. Volume 17:Number 5(2017)
• Page Start: 495
• Page End: 507
• Publication Date: 2017-05-04
• Subjects: Postpartum -- depression -- bipolar disorder -- mixed features -- treatment -- medication -- prevention -- prophylaxis -- lactation -- psychopharmacology; Neuropharmacology -- Periodicals; 615.7805
• DOI: 10.1080/14737175.2017.1265888
• Languages: English
• ISSNs: 1473-7175

Abstract

ABSTRACT: Introduction : Postpartum depression is a prevalent disorder affecting many women of reproductive age. Despite increasing public awareness, it is frequently underdiagnosed and undertreated leading to significant maternal morbidity and adverse child outcomes. When identified, postpartum depression is usually treated as major depressive disorder. Many studies have identified the postpartum as a period of high risk for first presentations and relapses of bipolar disorder. Areas c overed : This article reviews the acute and prophylactic treatment of postpartum major depressive disorder, bipolar depression and major depressive disorder with mixed features. The safety of antidepressant and mood stabilizing medications in pregnancy and breastfeeding will also be reviewed. Expert c ommentary : Differentiating postpartum major depressive disorder and postpartum bipolar depression can be difficult given their clinical similarities but accurate identification is vital for initiating proper treatment. Antidepressants are the mainstay of drug treatment for postpartum major depressive disorder, yet randomized controlled trials have shown conflicting results. A paucity of evidence exists for the effectiveness of antidepressant prophylaxis in the prevention of recurrences of major depressive disorder. Mood stabilizing medications reduce the risk of postpartum bipolar depression relapse but no randomized controlled trials have examined their use in the acute or prophylactic treatment of postpartum bipolar depression.