Rapid and visual detection of heparin based on the disassembly of polyelectrolyte-induced pyrene excimers. Issue 12 (7th March 2017)

• Record Type: Journal Article
• Authors: Qiao, Yadong; Yao, Zhiyi; Ge, Wenqi; Zhang, Li; Wu, Hai-Chen
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 12(2017)
• Page Start: 2569
• Page End: 2574
• Publication Date: 2017-03-07
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob00115k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A sensor based on polyelectrolyte-induced pyrene excimers has been developed for the visual detection of heparin with high sensitivity and selectivity. Abstract : We have developed a ratiometric sensor based on polyelectrolyte-induced pyrene excimers for the rapid and visual detection of heparin in aqueous media. This sensor has a simple preparation method, fast response, low cost, and high sensitivity and selectivity. As a complementary strategy for the detection of heparin based on the formation of pyrene excimers, this approach could identify heparin specifically over chondroitin sulphate, which is the major interferent in most sensing systems for the detection of heparin. The detection limit of this approach can be as low as 0.14 μM using fluorescence measurements. To the best of our knowledge, this is among the lowest LOD for the detection of heparin reported in the literature. It enables the rapid and visual detection of heparin both in buffered solution and serum samples.