One-pot synthesis of reactive oxygen species (ROS)-self-immolative polyoxalate prodrug nanoparticles for hormone dependent cancer therapy with minimized side effects. Issue 13 (13th March 2017)

• Record Type: Journal Article
• Authors: Höcherl, Anita; Jäger, Eliézer; Jäger, Alessandro; Hrubý, Martin; Konefał, Rafał; Janoušková, Olga; Spěváček, Jiří; Jiang, Yaming; Schmidt, Peter W.; Lodge, Timothy P.; Štěpánek, Petr
• Is Part Of: Polymer chemistry. Volume 8:Issue 13(2017)
• Page Start: 1999
• Page End: 2004
• Publication Date: 2017-03-13
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c7py00270j
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : One-pot synthesis of ROS-self-immolative polyoxalate prodrug NPs for cancer therapy. Abstract : A new reactive oxygen species (ROS)-sensitive, self-immolative biodegradable polyoxalate prodrug based on the anticancer chemotherapeutic hormone analog diethylstilbestrol was synthesized via one-pot step-growth polymerization. The nanoparticles prepared from this prodrug undergo self-immolative degradation releasing the chemotherapeutic drug in ROS-rich environments, e.g., in cancer cells. This new ROS self-immolative polyprodrug backbone eliminates the need for a linker between polymer chain and drug, resulting in a more specific drug release and minimized toxic side effects to non-ROS-producing cells as proven by in vitro experiments. The strategy enables re-utilization of a successful chemotherapeutic agent that has been clinically under-utilized due to dose-related side effects.