Adamantyl derivatives and rearranged benzophenones from Garcinia xanthochymus fruits. Issue 28 (21st March 2017)

• Record Type: Journal Article
• Authors: Chen, Yu; Gan, Fei; Jin, Shan; Liu, Hui; Wu, Shijun; Yang, Wenting; Yang, Guangzhong
• Is Part Of: RSC advances. Volume 7:Issue 28(2017)
• Page Start: 17289
• Page End: 17296
• Publication Date: 2017-03-21
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra01543g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Three new adamantyl derivatives and two new rearranged benzophenones from the fruits of G. xanthochymus displayed anti-proliferative activities. Abstract : Garcinia xanthochymus is a tropical fruit yielding tree native to South East Asia. Its fruit is used to treat bilious conditions, diarrhea and dysentery. In this study, three new adamantyl derivatives, two new rearranged benzophenones, named as garcixanthochymones A–E (1–5 ), together with 12 known compounds including 7 xanthones (6–12 ) and 5 flavonoids (13–17 ) were isolated from the fruits of G. xanthochymus . Their structures were elucidated by detailed spectroscopic analyses. All isolated compounds were evaluated for their anti-proliferative activities against four human tumor cells (HepG2, A549, SGC7901, MCF-7). Adamantyl derivatives (1–3 ) and rearranged benzophenones (4–5 ) displayed potential inhibitory activity against four human cancer cell lines with IC50 values of 5.16–16.45 μM. These data suggested that the extracts of the fruits of G. xanthochymus are potent candidates for cancer prevention.