Encapsulation of aggregated gold nanoclusters in a metal–organic framework for real-time monitoring of drug release. Issue 12 (10th March 2017)

• Record Type: Journal Article
• Authors: Cao, Fangfang; Ju, Enguo; Liu, Chaoqun; Li, Wei; Zhang, Yan; Dong, Kai; Liu, Zhen; Ren, Jinsong; Qu, Xiaogang
• Is Part Of: Nanoscale. Volume 9:Issue 12(2017)
• Page Start: 4128
• Page End: 4134
• Publication Date: 2017-03-10
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c7nr00073a
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Aggregated gold nanoclusters (aAuNCs) were confined in a MOF to improve their quantum yield (QY) to 7.74%. Abstract : Gold nanoclusters (AuNCs), which have stable luminescence and negligible biotoxicity, are a promising candidate in biological fields. However, their low photoluminescence (PL) efficiency is unsatisfactory. Herein, aggregated gold nanoclusters (aAuNCs) were confined in a metal–organic framework (MOF) to maintain their aggregation, restrict the rotation of their ligands, and further improve their quantum yield (QY) to 7.74%. The aAuNCs-MOF exhibited high luminescence and good biocompatibility. More importantly, in addition to its pH-dependent luminescence and external porosity, the complex was applied for the first time in real-time monitoring of drug release.