A two-photon fluorescent probe for real-time monitoring of autophagy by ultrasensitive detection of the change in lysosomal polarity. Issue 26 (28th February 2017)

• Record Type: Journal Article
• Authors: Jiang, Jiacheng; Tian, Xiaohe; Xu, Changzhi; Wang, Shuxin; Feng, Yan; Chen, Man; Yu, Haizhu; Zhu, Manzhou; Meng, Xiangming
• Is Part Of: Chemical communications. Volume 53:Issue 26(2017)
• Page Start: 3645
• Page End: 3648
• Publication Date: 2017-02-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc00752c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The first two-photon probe, Lyso-OC, was proposed for use in monitoring cell autophagy by detection of the change in the lysosomal polarity during the membrane fusion process. Abstract : The first two-photon probe, Lyso-OC, was proposed for use in monitoring cell autophagy by detection of the change in the lysosomal polarity during the membrane fusion process of autophagy. TheLyso-OC probe exhibited desirable optical properties and a detection signal that was selective to the polarity change. More importantly, Lyso-OC displayed real-time monitoring of autophagy in living cells.