An efficient approach to 3-oxoisoindoline-1-difluoroalkyl derivatives via a metal triflate-catalyzed Mannich/lactamization cascade reaction. (13th March 2017)

• Record Type: Journal Article
• Authors: Chen, Tingting; Cai, Chun
• Is Part Of: New journal of chemistry. Volume 41:Number 7(2017)
• Page Start: 2519
• Page End: 2522
• Publication Date: 2017-03-13
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c6nj03813a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : An efficient approach for the synthesis of N -substituted 3-oxoisoindoline-1-difluoroalkyl derivatives via a one-pot cascade reaction has been developed. Abstract : An efficient approach for the synthesis of N -substituted 3-oxoisoindoline-1-difluoroalkyl derivatives via a one-pot cascade reaction has been developed. The reaction proceeded smoothly in the presence of In(OTf)3 and afforded a broad scope of isoindolinones with moderate to good yields. Moreover, the reaction could be run on a gram-scale with comparable yield.