Rearrangement of vinyl allene oxide geometric isomers to cyclopentenones. Further computational insights with biologically relevant model systems. Issue 13 (13th March 2017)

• Record Type: Journal Article
• Authors: González-Pérez, Adán B.; Grechkin, Alexander; de Lera, Ángel R.
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 13(2017)
• Page Start: 2846
• Page End: 2855
• Publication Date: 2017-03-13
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob02791a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A computational study of the rearrangement of vinyl allene oxides of biological relevance, which include alkyl (methyl, propyl) or unsaturated groups (allyl, crotyl) attached to the Csp 3 atom has revealed interesting insights into the formation of naturally occurring cyclopentenones. Abstract : Pathways for the rearrangement of the E and Z isomers of allyl- and methyl-substituted vinyl allene oxides to stereodefined cyclopentenones have been studied by DFT computations. Regardless of the reactant geometry, cis -configured cyclopentenones are found to be formed in a stepwise cascade comprising as key steps the ring opening of the oxirane to give an oxidopentadienyl diradical, its isomerization, and electrocyclization. An allyl substituent at the Csp 3 atom of the starting vinyl allene oxide induces opposite effects on the activation energies for ring opening: a decrease owing to assistance by homoconjugation for the out motion and an increase due to the stereoelectronic stabilization of the reactant. As a result, allyl- and methyl-substituted vinyl allene oxides exhibit comparable activation energies. Only model systems with crotyl substituents afford lower activation energies than the methyl counterparts due to the additional stabilization of the forming charge deficiency at a secondary carbon by homoconjugation. Moreover, upon homoconjugative interaction reactants of Z geometry are predicted to undergo cyclization more readily than the E isomers. The results with Z -crotyl substituent are congruent with the spontaneous rearrangement of natural vinyl allene oxide derived from α-linolenic acid to a racemic cis -cyclopentenone (12-oxo-PDA).