Asymmetric hydrogenation of α-hydroxy ketones with an iridium/f-amphox catalyst: efficient access to chiral 1, 2-diols. Issue 4 (19th January 2017)

• Record Type: Journal Article
• Authors: Wu, Weilong; Xie, Yun; Li, Pan; Li, Xiuxiu; Liu, Yuanhua; Dong, Xiu-Qin; Zhang, Xumu
• Is Part Of: Organic chemistry frontiers. Volume 4:Issue 4(2017)
• Page Start: 555
• Page End: 559
• Publication Date: 2017-01-19
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c6qo00810k
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : We successfully applied f-amphox ligands to the Ir-catalyzed asymmetric hydrogenation of α-hydroxy ketones to afford chiral 1, 2-diols with excellent results. Abstract : We successfully applied tridentate f-amphox ligands to the iridium-catalytic asymmetric hydrogenation of various α-hydroxy ketones to afford the corresponding chiral 1, 2-diols with excellent results (almost all products up to 99% yield and >99% ee). The resulting chiral 1, 2-diols and their derivatives are important synthetic and pharmaceutical intermediates. Our catalytic system displayed extremely high activity, achieving up to 1 000 000 turnover number (TON). The great performance of this asymmetric hydrogenation makes the preparation of various chiral 1, 2-diols highly practical with great potential.