An efficient method for regioselective ring opening of epoxides by amines under microwave irradiation using Bi(NO3)3·5H2O as a catalyst. (9th March 2017)

• Record Type: Journal Article
• Authors: Bansal, Shobha; Kumar, Yogendra; Pippal, Parveen; Das, Dipak K.; Pramanik, Panchanan; Singh, Prabal P.
• Is Part Of: New journal of chemistry. Volume 41:Number 7(2017)
• Page Start: 2668
• Page End: 2671
• Publication Date: 2017-03-09
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c6nj03701a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Bi(NO3 )3 ·5H2 O a highly efficient environmentally benign catalyst, is used for the nucleophilic ring opening of epoxides with aromatic, aliphatic and heteroaromatic amines under solvent free microwave conditions to afford the corresponding β-amino alcohols in good to excellent yields with high regioselectivity. Abstract : Bismuth(iii )nitrate pentahydrate, a highly efficient environmentally benign catalyst, is used for the nucleophilic ring opening of epichlorohydrin and styrene oxide with aromatic, aliphatic and heteroaromatic amines under solvent free microwave conditions reducing the reaction time drastically to afford the corresponding β-amino alcohols in good to excellent yields with high regioselectivity. The products obtained were directly purified by column chromatography and characterised by 1 H & 13 C NMR, FTIR and mass spectroscopy.