A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells. Issue 26 (15th March 2017)

• Record Type: Journal Article
• Authors: Reja, Shahi Imam; Gupta, Muskan; Gupta, Neha; Bhalla, Vandana; Ohri, Puja; Kaur, Gurcharan; Kumar, Manoj
• Is Part Of: Chemical communications. Volume 53:Issue 26(2017)
• Page Start: 3701
• Page End: 3704
• Publication Date: 2017-03-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc09127j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A lysosome targetable naphthalimide based fluorescent probe has been designed and synthesized for selective imaging of H2 O2 in different cells, tissues and in vivo models. Abstract : A lysosome targetable naphthalimide based fluorescent probe (LyNC) has been designed and synthesized which detects hydrogen peroxide (H2 O2 ) with high selectivity and sensitivity in brain tissues and in living nematodes among various ROS/RNS tested. Further, the probeLyNC was successfully employed in exogenous and endogenous imaging of H2 O2 in living cell lines.