Redox-responsive dextran based theranostic nanoparticles for near-infrared/magnetic resonance imaging and magnetically targeted photodynamic therapy. (3rd March 2017)

• Record Type: Journal Article
• Authors: Ding, Zexuan; Liu, Peng; Hu, Dehong; Sheng, Zonghai; Yi, Huqiang; Gao, Guanhui; Wu, Yayun; Zhang, Pengfei; Ling, Shaozhi; Cai, Lintao
• Is Part Of: Biomaterials science. Volume 5:Number 4(2017:Apr.)
• Page Start: 762
• Page End: 771
• Publication Date: 2017-03-03
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/c6bm00846a
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : A multifunctional theranostic nanoparticle system for near-infrared (NIR)/magnetic resonance (MR) dual-modality imaging and magnetic targeting. Abstract : Photodynamic therapy (PDT) is a site-specific treatment of cancer using much lower optical power densities with minimal nonspecific damage to normal tissues. To improve the therapeutic efficiency of PDT, we fabricated a multifunctional theranostic nanoparticle system (DSSCe6@Fe3 O4 NPs) by loading Fe3 O4 nanoparticles in redox-responsive chlorin e6 (Ce6)-conjugated dextran nanoparticles for near-infrared (NIR)/magnetic resonance (MR) dual-modality imaging and magnetic targeting. The obtained DSSCe6@Fe3 O4 NPs demonstrated a uniform nanospherical morphology consisting of Fe3 O4 clusters. The fluorescence signal of Ce6 of this theranostic system could turn "ON" from a self-quenching state in a reductive intracellular environment. T 2 -Weighted MR imaging revealed a high transverse relaxivity ( r 2 ) measured to be 194.4 S −1 mM −1, confirming that it was also a distinctive contrast agent in T 2 -weighted MR imaging. Confocal images and flow cytometry results showed that the cellular uptake of DSSCe6@Fe3 O4 NPs was enhanced effectively under an extra magnetic field, which resulted in promoted PDT therapeutic efficiency. In vivo MR imaging showed that DSSCe6@Fe3 O4 NPs effectively accumulated in tumors under an extra magnetic field. These results illustrated that the DSSCe6@Fe3 O4 NPs could be a promising theranostic system for both NIR/MR imaging-guided PDT precision therapy.