One‐hour postload plasma glucose concentration in people with normal glucose homeostasis predicts future diabetes mellitus: a 12‐year community‐based cohort study. (28th November 2016)

• Record Type: Journal Article
• Authors: Oh, Tae Jung; Lim, Soo; Kim, Kyoung Min; Moon, Jae Hoon; Choi, Sung Hee; Cho, Young Min; Park, Kyong Soo; Jang, HakChul; Cho, Nam H.
• Is Part Of: Clinical endocrinology. Volume 86:Number 4(2017)
• Page Start: 513
• Page End: 519
• Publication Date: 2016-11-28
• Subjects: Endocrinology -- Periodicals; 616.4005
• DOI: 10.1111/cen.13280
• Languages: English
• ISSNs: 0300-0664

Abstract

Summary: Objective: In Caucasians, plasma glucose concentration at 1 h during an oral glucose tolerance test (OGTT) may be a better predictor of future diabetes mellitus than the fasting or 2‐h postload glucose concentration. We investigated whether the 1‐h glucose concentration could be used to predict future diabetes mellitus in Asian ethnicity. Measurements: A total of 5703 Koreans with normal glucose tolerance were enrolled from the Korean Genome and Epidemiology Study. Indices of insulin sensitivity and β‐cell function estimated from standard 75‐g OGTTs performed every 2 years for 12 years were used to identify whether the 1‐h glucose concentration could predict future diabetes mellitus. Results: The mean age and body mass index at baseline were 51·3 ± 8·7 years and 24·2 ± 3·0 kg/m 2, respectively. During the 12‐year follow‐up, 593 subjects (10·3%) developed diabetes mellitus. The area under the receiver‐operating characteristic curve for incident diabetes mellitus was higher for the 1‐h postload glucose concentration than for the fasting or postload 2‐h glucose concentration (0·74 vs 0·61 or 0·63). The cut‐off value of ≥8·0 mmol/l identified incident diabetes mellitus with 70% sensitivity and 68% specificity. After adjusting for typical risk factors, subjects with a 1‐h postload glucose concentration ≥8·0 mmol/l had lower β‐cell function and a 2·84‐fold increased risk of incident diabetes mellitus compared with their counterparts. Conclusions: In this community‐based 12‐year prospective cohort study, 1‐h postload plasma glucose concentration was an independent predictor of future diabetes mellitus and 8·0 mmol/l was suggested as a cut‐off value.