Concentrations dominated membrane permeability variation by fullerol nanoparticles on a single living HeLa cell. Issue 34 (15th August 2016)

• Record Type: Journal Article
• Authors: Liu, Naiyun; Han, Mumei; Zhang, Yalin; Wu, Xiuqin; Liu, Juan; Li, Hao; Cao, Tiantian; Nan, Xueyan; Huang, Hui; Liu, Yang; Chen, Ning; Wang, Chunru; Kang, Zhenhui
• Is Part Of: Journal of materials chemistry. Volume 4:Issue 34(2016)
• Page Start: 5755
• Page End: 5760
• Publication Date: 2016-08-15
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c6tb01474g
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : The effects in HeLa cell membrane permeability caused by the fullerenols C60 (OH) n with different concentrations were studied by scanning electrochemical microscopy (SECM). Abstract : The effects in HeLa cell membrane permeability caused by the fullerenols C60 (OH) n with different concentrations were studied by scanning electrochemical microscopy (SECM). We demonstrate that C60 (OH) n has very low cytotoxicity, although it can still have strong effects on the cell membrane permeability. In the presence of 1 × 10 −3 mg mL −1 (1 ppm) C60 (OH) n, the cell membrane permeability increases by 26% after 76 min, which is reversible. When C60 (OH) n concentration is over 25 × 10 −3 mg mL −1 (25 ppm), the change in membrane permeability (increased 19%) is irreversible.