An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H2O2. Issue 33 (5th August 2016)

• Record Type: Journal Article
• Authors: Leung, Anakin C. S.; Zhao, Engui; Kwok, Ryan T. K.; Lam, Jacky W. Y.; Leung, Chris W. T.; Deng, Haiqin; Tang, Ben Zhong
• Is Part Of: Journal of materials chemistry. Volume 4:Issue 33(2016)
• Page Start: 5510
• Page End: 5514
• Publication Date: 2016-08-05
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c6tb01734g
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A bioprobe, TPE–Zn2 BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H2 O2 . Abstract : A bioprobe, TPE–Zn2 BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H2 O2 . TPE–Zn2 BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both stages with brighter fluorescence in the late apoptotic stage.