Synthetic lethality: emerging targets and opportunities in melanoma. (11th March 2017)

• Record Type: Journal Article
• Authors: Thompson, Nicola; Adams, David J.; Ranzani, Marco
• Is Part Of: Pigment cell & melanoma research. Volume 30:Number 2(2017)
• Page Start: 183
• Page End: 193
• Publication Date: 2017-03-11
• Subjects: synthetic lethality -- CRISPR -- melanoma genomics -- preclinical models -- therapeutic target; Melanoma -- Periodicals; Chromatophores -- Periodicals; Animal pigments -- Periodicals; 616.99477
• DOI: 10.1111/pcmr.12573
• Languages: English
• ISSNs: 1755-1471

Abstract

Summary: Great progress has been made in the treatment of melanoma through use of targeted therapies and immunotherapy. One approach that has not been fully explored is synthetic lethality, which exploits somatically acquired changes, usually driver mutations, to specifically kill tumour cells. We outline the various approaches that may be applied to identify synthetic lethal interactions and define how these interactions may drive drug discovery efforts.