A significant productive in vivo infection of resting cells with simian immunodeficiency virus in a macaque with AIDS. Issue 2 (1st February 2017)

• Record Type: Journal Article
• Authors: Pahar, Bapi; Lala, Wendy; Kuebler, Dot; Liu, David
• Is Part Of: Journal of medical primatology. Volume 46:Issue 2(2017)
• Page Start: 59
• Page End: 62
• Publication Date: 2017-02-01
• Subjects: infection -- macrophage -- reservoir -- resting cells -- simian immunodeficiency virus -- simian immunodeficiency virus RNA -- T cells; Primates -- Periodicals; Primates -- Diseases -- Periodicals; Medicine, Experimental -- Periodicals; 616.02738
• DOI: 10.1111/jmp.12252
• Languages: English
• ISSNs: 0047-2565

Abstract

Abstract: Identifying the cells that can be infected with HIV in vivo and thus potentially persist as latent reservoirs is of high priority. Here, we report the major infected cells in a chronically simian immunodeficiency virus (SIV)‐infected macaque that developed AIDS and encephalitis. A majority of the infected cells were detected as non‐proliferating resting cells. SIV‐infected non‐proliferating resting cells were found to be playing an important role in viral pathogenesis, persistence, or reservoir formation.