An Easy Access to Construct Some New Fused 1, 2, 4‐Triazines with Ring Junction Nitrogen Systems and Their Biological Evaluation. (22nd July 2016)

• Record Type: Journal Article
• Authors: Hamama, Wafaa; El‐Bana, Ghada; Shaaban, Saad; Habib, O. M. O.; Zoorob, Hanafi
• Is Part Of: Journal of heterocyclic chemistry. Volume 54:Number 2(2017:Mar.)
• Page Start: 1384
• Page End: 1390
• Publication Date: 2016-07-22
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2718
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : The chemical reactivity of 4‐amino‐6‐benzyl‐3‐mercapto‐1, 2, 4‐triazine‐5(4 H )‐one (1 ) towards various aliphatic or/and mono and bis aromatic carboxylic acid derivatives to give the corresponding fused heterocyclic systems, 1, 3, 4‐thiadiazoles4, 5, 6, which incorporating 1, 2, 4‐triazine moiety was achieved. Moreover, compound1 was subjected to reaction either with halo acetic acids or bromo ester to afford the respective fused nitrogen ring junction systems, thiadiazole2 and3 or thiadiazine7 . However, while the tetracyclic ring system9 was furnished throughcondensation reaction of isatine with triazine1 . In addition, some of the new synthesized compounds were evaluated as an antioxidant andantitumor agents . Abstract :