Adjunctive efficacy of probiotics in the treatment of experimental peri‐implant mucositis with mechanical and photodynamic therapy: a randomized, cross‐over clinical trial. (18th February 2017)

• Record Type: Journal Article
• Authors: Mongardini, Claudio; Pilloni, Andrea; Farina, Roberto; Di Tanna, Gianluca; Zeza, Blerina
• Is Part Of: Journal of clinical periodontology. Volume 44:Number 4(2017:Apr.)
• Page Start: 410
• Page End: 417
• Publication Date: 2017-02-18
• Subjects: dental implants -- mucositis -- photochemotherapy -- probiotics; Periodontics -- Periodicals; 617.6
• DOI: 10.1111/jcpe.12689
• Languages: English
• ISSNs: 0303-6979

Abstract

Abstract: Aim: To evaluate the adjunctive clinical efficacy of probiotics in the treatment of peri‐implant mucositis (p‐iM) with professionally administered plaque removal (PAPR) and photodynamic therapy (PDT). Materials and methods: Following p‐iM induction, patients underwent PAPR + PDT and were randomly assigned to receive the professional and home‐based administration of probiotics ( Lactobacillus plantarum and Lactobacillus brevis ) (test treatment) or placebo preparation (control treatment) according to a cross‐over design. Clinical parameters were assessed at six sites for each implant before as well as at 2 and 6 weeks after professional treatment administration. Results: Twenty patients contributing one dental implant each were included. Immediately before treatment and at 6 weeks, the median number of sites with bleeding on probing (BoP+) sites per implant unit was 4 (3–6) and 2 (0–2) ( p < 0.001), respectively, for test treatment, and 3.5 (2–4) and 2 (0–3) ( p = 0.03), respectively, for control treatment. No significant difference in clinical outcomes was observed between treatment groups. Conclusion: The combination of PAPR and PDT either alone or associated with probiotics determined a significant reduction in the number of BoP+ sites at 2 and 6 weeks around implants with p‐iM. The adjunctive use of probiotics did not significantly enhance the clinical outcomes of PAPR + PDT.