Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats. Issue 4 (5th January 2017)

• Record Type: Journal Article
• Authors: Alves, Naiane Ferraz Bandeira; de Queiroz, Thyago Moreira; de Almeida Travassos, Rafael; Magnani, Marciane; de Andrade Braga, Valdir
• Is Part Of: Basic & clinical pharmacology & toxicology. Volume 120:Issue 4(2017)
• Page Start: 348
• Page End: 353
• Publication Date: 2017-01-05
• Subjects: Pharmacology -- Periodicals; Toxicology -- Periodicals; Pharmacology -- Periodicals; Toxicology -- Periodicals; Pharmacology, Clinical -- Periodicals; Computer network resources; Electronic journals; 615.1
• DOI: 10.1111/bcpt.12700
• Languages: English
• ISSNs: 1742-7835

Abstract

Abstract: The effects of acute administration of lauric acid (LA), the most abundant medium‐chain fatty acid of coconut oil, on blood pressure, heart rate and oxidative stress were investigated in spontaneously hypertensive rats (SHR). Intravenous doses of LA reduced blood pressure in a dose‐dependent fashion (1, 3, 4, 8 and 10 mg/kg) in both SHR and Wistar Kyoto rats. LA (10 −8 to 3 × 10 −3 M) induced vasorelaxation in isolated superior mesenteric artery rings of SHR in the presence (n = 7) or absence (n = 8) of functional endothelium [maximum effect (ME) = 104 ± 3 versus 103 ± 4%]. After exposure to KCl (60 mM), LA also induced concentration‐dependent vasorelaxation (n = 7) compared to that under Phe‐induced contraction (ME = 113.5 + 5.1 versus 104.5 + 4.0%). Furthermore, LA‐induced vasorelaxation in vessels contracted with S(−)‐BayK8644 (200 nM), a L‐type Ca 2+ channel agonist (ME = 91.4 + 4.3 versus 104.5 + 4.0%, n = 7). Lastly, LA (10 −3 M) reduced NADPH‐dependent superoxide accumulation in the heart (18 ± 1 versus 25 ± 1 MLU/min/μg protein, n = 4, p < 0.05) and kidney (82 ± 3 versus 99 ± 4 MLU/min/μg protein, n = 4, p < 0.05). Our data show that LA reduces blood pressure in normotensive and hypertensive rats. In SHR, this effect might involve Ca +2 channels in the resistance vessels and by its capability of reducing oxidative stress in heart and kidneys.