Gold nanoshell coated thermo-pH dual responsive liposomes for resveratrol delivery and chemo-photothermal synergistic cancer therapy. Issue 11 (2nd March 2017)

• Record Type: Journal Article
• Authors: Wang, Meili; Liu, Yanping; Zhang, Xuwu; Luo, Liyao; Li, Lei; Xing, Shanshan; He, Yuchu; Cao, Weiwei; Zhu, Ruiyan; Gao, Dawei
• Is Part Of: Journal of materials chemistry. Volume 5:Issue 11(2017)
• Page Start: 2161
• Page End: 2171
• Publication Date: 2017-03-02
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7tb00258k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Stimuli-responsive drug delivery and release have a great significance in cancer therapy. Abstract : Stimuli-responsive drug delivery and release have a great significance in cancer therapy. Herein, a multifunctional responsive drug carrier was designed and developed by loading resveratrol (Res) in chitosan (CTS) modified liposomes, and coated by gold nanoshells (GNS@CTS@Res-lips). The resultant GNS@CTS@Res-lips possess broad near-infrared (NIR) absorbance, high capability, stability, and also high photothermal conversion ability for efficient photothermal therapy (PTT) applications. In addition, the GNS@CTS@Res-lips exhibit the on-demand pH/photothermal-sensitive drug release, and a high loading capacity of Res. Under NIR laser irradiation, the drug delivery system could significantly enhance the cellular uptake of drugs. More importantly, compared to the single chemotherapy or PTT, the carriers with NIR irradiation displayed a higher therapeutic effect for HeLa cells. Therefore, the GNS@CTS@Res-lips with a combination of chemotherapy and PTT will show great potential for application in cancer therapy.