Diversity-oriented synthesis and cytotoxic activity evaluation of biaryl-containing macrocycles. Issue 11 (3rd March 2017)

• Record Type: Journal Article
• Authors: Pérez-Labrada, Karell; Cruz-Mendoza, Marco A.; Chávez-Riveros, Alejandra; Hernández-Vázquez, Eduardo; Torroba, Tomás; Miranda, Luis D.
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 11(2017)
• Page Start: 2450
• Page End: 2458
• Publication Date: 2017-03-03
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob02726a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Synthesis of biaryl-containing macrocycles has been carried out through a four-step approach comprising two Ugi four component reactions and a Suzuki–Miyaura macrocyclization. Abstract : Synthesis of biaryl-containing macrocycles has been carried out through a four-step approach comprising two Ugi four component reactions and a Suzuki–Miyaura macrocyclization. This protocol allowed the synthesis of 12- and 14-membered macrocycles. Cytotoxic activity evaluation showed that some of the molecules were effective against leukemia, glioblastoma and lung cancer cell lines (IC50 = 4.0, 5.9 and 7.6, respectively).