Mechanistic investigations of the asymmetric hydrosilylation of ketimines with trichlorosilane reveals a dual activation model and an organocatalyst with enhanced efficiency. Issue 11 (2nd March 2017)

• Record Type: Journal Article
• Authors: Li, X.; Reeder, A. T.; Torri, F.; Adams, H.; Jones, S.
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 11(2017)
• Page Start: 2422
• Page End: 2435
• Publication Date: 2017-03-02
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob02537d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Mechanistic investigations of a catalyst used for the asymmetric hydrosilylation have revealed a 'dual activation' model and catalyst that maintains its performance at 0.01 mol% loading. Abstract : Structural probes used to help elucidate mechanistic information of the organocatalyzed asymmetric ketimine hydrosilylation have revealed a new catalyst with unprecedented catalytic activity, maintaining adequate performance at 0.01 mol% loading. A new 'dual activation' model has been proposed that relies on the presence of both a Lewis basic and Brønsted acidic site within the catalyst architecture.