Impact of Nonoptimal Intakes of Saturated, Polyunsaturated, and Trans Fat on Global Burdens of Coronary Heart Disease. Issue 1 (January 2016)

• Record Type: Journal Article
• Authors: Wang, Qianyi; Afshin, Ashkan; Yakoob, Mohammad Yawar; Singh, Gitanjali M.; Rehm, Colin D.; Khatibzadeh, Shahab; Micha, Renata; Shi, Peilin; Mozaffarian, Dariush
• Other Names: Mozaffarian Dariush investigator.; Micha Renata investigator.; Shi Peilin investigator.; Ezzati Majid investigator.; Fahimi Saman investigator.; Khatibzadeh Shahab investigator.; Powles John investigator.; Elmadfa Ibrahim investigator.; Rao Mayuree investigator.; Wirojratana Pattra investigator.; Lim Stephen S. investigator.; Engell Rebecca E. investigator.; Andrews Kathryn G. investigator.; Abbott Pamela A. investigator.; Abdollahi Morteza investigator.; Abeyá Gilardon Enrique O. investigator.; Ahsan Habibul investigator.; Al Nsour Mohannad Abed Alfattah investigator.; Al‐Hooti Suad N. investigator.; Arambepola Carukshi investigator.; Barennes Hubert investigator.; Barquera Simon investigator.; Baylin Ana investigator.; Becker Wulf investigator.; Bjerregaard Peter investigator.; Bourne Lesley T. investigator.; Calleja Neville investigator.; Castetbon Katia investigator.; Chang Hsing‐Yi investigator.; Cowan Melanie J. investigator.; De Henauw Stefaan investigator.; Ding Eric L. investigator.; Duante Charmaine A. investigator.; Duran Pablo investigator.; Elmadfa Ibrahim investigator.; Barbieri Heléne Enghardt investigator.; Farzadfar Farshad investigator.; Fernando Dulitha N. investigator.; Hadziomeragic Aida Filipovic investigator.; Fisberg Regina M. investigator.; Forsyth Simon investigator.; Garriguet Didier investigator.; Gaspoz Jean‐Michel investigator.; Gauci Dorothy investigator.; Ginnela Brahmam N. V. investigator.; Guessous Idris investigator.; Hadden Wilbur investigator.; Hoffman Daniel J. investigator.; Houshiar‐Rad Anahita investigator.; Huybrechts Inge investigator.; Hwalla Nahla C. investigator.; Ibrahim Hajah Masni investigator.; Inoue Manami investigator.; Jackson Maria D. investigator.; Johansson Lars investigator.; Keinan‐Boker Lital investigator.; Kim Cho‐il investigator.; Koksal Eda investigator.; Lee Hae‐Jeung investigator.; Li Yanping investigator.; Lipoeto Nur Indrawaty investigator.; Ma Guansheng investigator.; Mangialavori Guadalupe L. investigator.; Matsumura Yasuhiro investigator.; McGarvey Stephen T. investigator.; Fen Chan Mei investigator.; Monge‐Rojas Rafael A. investigator.; Musaiger Abdulrahman Obaid investigator.; Nagalla Balakrishna investigator.; Naska Androniki investigator.; Ocke Marga C. investigator.; Oltarzewski Maciej investigator.; Orfanos Philippos investigator.; Ovaskainen Marja‐Leena investigator.; Pan Wen‐Harn investigator.; Panagiotakos Demosthenes B. investigator.; Pekcan Gulden Ayla investigator.; Petrova Stefka investigator.; Piaseu Noppawan investigator.; Pitsavos Christos investigator.; Posada Luz Gladys investigator.; Riley Leanne M. investigator.; Sánchez‐Romero Luz Maria investigator.; Selamat Rusidah B. T. investigator.; Sharma Sangita investigator.; Sibai Abla Mehio investigator.; Sichieri Rosely investigator.; Simmala Chansimaly investigator.; Steingrimsdottir Laufey investigator.; Swan Gillian investigator.; Sygnowska Elżbieta Halina investigator.; Szponar Lucjan investigator.; Tapanainen Heli investigator.; Templeton Robert investigator.; Thanopoulou Anastasia investigator.; Thorgeirsdóttir Holmfridur investigator.; Thorsdottir Inga investigator.; Trichopoulou Antonia investigator.; Tsugane Shoichiro investigator.; Turrini Aida investigator.; Vaask Sirje investigator.; van Oosterhout Coline investigator.; Veerman J Lennert investigator.; Verena Nowak investigator.; Waskiewicz Anna investigator.; Zaghloul Sahar investigator.; Zajkás Gábor investigator.;
• Is Part Of: Journal of the American Heart Association. Volume 5:Issue 1(2016:Jan.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-01
• Subjects: cardiovascular disease -- coronary heart disease -- dietary fat -- ω‐6 polyunsaturated fat -- saturated fat -- trans fat; Heart -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cerebrovascular disease -- Periodicals; Cardiology -- Periodicals; 616.1
• DOI: 10.1161/JAHA.115.002891
• Languages: English
• ISSNs: 2047-9980

Abstract

Abstract : Background: Saturated fat (SFA), ω‐6 (n‐6) polyunsaturated fat (PUFA), and trans fat (TFA) influence risk of coronary heart disease (CHD), but attributable CHD mortalities by country, age, sex, and time are unclear. Methods and Results: National intakes of SFA, n‐6 PUFA, and TFA were estimated using a Bayesian hierarchical model based on country‐specific dietary surveys; food availability data; and, for TFA, industry reports on fats/oils and packaged foods. Etiologic effects of dietary fats on CHD mortality were derived from meta‐analyses of prospective cohorts and CHD mortality rates from the 2010 Global Burden of Diseases study. Absolute and proportional attributable CHD mortality were computed using a comparative risk assessment framework. In 2010, nonoptimal intakes of n‐6 PUFA, SFA, and TFA were estimated to result in 711 800 (95% uncertainty interval [UI] 680 700–745 000), 250 900 (95% UI 236 900–265 800), and 537 200 (95% UI 517 600–557 000) CHD deaths per year worldwide, accounting for 10.3% (95% UI 9.9%–10.6%), 3.6%, (95% UI 3.5%–3.6%) and 7.7% (95% UI 7.6%–7.9%) of global CHD mortality. Tropical oil–consuming countries were estimated to have the highest proportional n‐6 PUFA– and SFA‐attributable CHD mortality, whereas Egypt, Pakistan, and Canada were estimated to have the highest proportional TFA‐attributable CHD mortality. From 1990 to 2010 globally, the estimated proportional CHD mortality decreased by 9% for insufficient n‐6 PUFA and by 21% for higher SFA, whereas it increased by 4% for higher TFA, with the latter driven by increases in low‐ and middle‐income countries. Conclusions: Nonoptimal intakes of n‐6 PUFA, TFA, and SFA each contribute to significant estimated CHD mortality, with important heterogeneity across countries that informs nation‐specific clinical, public health, and policy priorities.