Intraobserver Agreement on Histopathologic Evaluations of Core Breast Biopsies. Issue 2 (20th November 2016)

• Record Type: Journal Article
• Authors: Trocchi, Pietro; Holzhausen, Hans‐Jürgen; Löning, Thomas; Böcker, Werner; Schmidt‐Pokrzywniak, Andrea; Thomssen, Christoph; Kluttig, Alexander; Stang, Andreas
• Is Part Of: Breast journal. Volume 23:Issue 2(2017:Mar./Apr.)
• Page Start: 215
• Page End: 219
• Publication Date: 2016-11-20
• Subjects: breast -- classification pathology -- core needle biopsy -- diagnosis -- reliability; Breast -- Diseases -- Periodicals; Breast -- Cancer -- Periodicals; 618.19
• DOI: 10.1111/tbj.12708
• Languages: English
• ISSNs: 1075-122X

Abstract

Abstract: The number of performed core biopsies of the breast as diagnostic workup is increasing in many European countries. We measured the intraobserver variability in pathological assessment of breast core biopsies. Furthermore, we studied potential modifiers of agreement between the assessments. Two hundred and fifty‐six breast biopsies were evaluated twice in a blinded fashion by two pathologists. We calculated the observed and the chance‐corrected (weighted) intraobserver agreement (kappa) using the B‐categorization scheme (B1: normal or not interpretable, B2: benign, B3: benign but of uncertain biological potential, B4: suspicious of malignancy, B5: malignant). The observed agreement between the first and the second assessments were 0.80 (95% CI: 0.75–0.85) for pathologist 1 and 0.81 (95% CI: 0.76–0.86) for pathologist 2. The chance‐corrected agreements were 0.85 (95% CI: 0.80–0.89) and 0.81 (95% CI: 0.76–0.87), respectively. The most frequent disagreement was between B1 and B2 for pathologist 1 ( N = 34 out of 50 disagreements, 68%) and between B2 and B3 for pathologist 2 ( N = 23 out of 48 disagreements, 48%). Our study shows that the chance‐corrected agreement between the histopathological evaluations of breast biopsies based on the B‐categorization scheme is almost perfect. The level of agreement is modified by biopsy technique and by the level of suspicion of the mammographic lesion.