Building confidence in quantitative systems pharmacology models: An engineer's guide to exploring the rationale in model design and development. (9th February 2017)

• Record Type: Journal Article
• Authors: Timmis, J; Alden, K; Andrews, P; Clark, E; Nellis, A; Naylor, B; Coles, M; Kaye, P
• Is Part Of: CPT: pharmacometrics & systems pharmacology. Volume 6:Number 3(2017)
• Page Start: 156
• Page End: 167
• Publication Date: 2017-02-09
• Subjects: Pharmacokinetics -- Periodicals; Pharmacology -- Periodicals; Pharmacokinetics; Periodicals; 615.05
• DOI: 10.1002/psp4.12157
• Languages: English
• ISSNs: 2163-8306

Abstract

Abstract : This tutorial promotes good practice for exploring the rationale of systems pharmacology models. A safety systems engineering inspired notation approach provides much needed rigor and transparency in development and application of models for therapeutic discovery and design of intervention strategies. Structured arguments over a model's development, underpinning biological knowledge, and analyses of model behaviors are constructed to determine the confidence that a model is fit for the purpose for which it will be applied.