Cancer stem cells: small subpopulation or evolving fraction?. Issue 1 (31st October 2014)

• Record Type: Journal Article
• Authors: Enderling, Heiko
• Is Part Of: Integrative biology. Volume 7:Issue 1(2015:Jan.)
• Page Start: 14
• Page End: 23
• Publication Date: 2014-10-31
• Subjects: Biology -- Periodicals; Technology -- Periodicals; Biological systems -- Periodicals; 570.5
• DOI: 10.1039/c4ib00191e
• Languages: English
• ISSNs: 1757-9694

Abstract

Abstract : This review discusses quantitative modeling studies of stem and non-stem cancer cell interactions and the fraction of cancer stem cells. Abstract : Central to the debate about cancer stem cells in solid tumors is the proportion of cells that can initiate, propagate, and re-initiate tumors. An initially assumed minor subpopulation is confronted with recent data suggesting as many as 30% of primary tumor cells have stem cell characteristics. This review discusses quantitative modeling studies that augment our understanding of stem and non-stem cancer cell interactions during tumor progression and the resulting fraction of cancer stem cells. A discussion of how these findings can be carefully evaluated in novel, integrated interdisciplinary studies is offered.