Estrogen receptor 1 gene rs2295193 polymorphism and anorexia nervosa: New data and meta‐analysis. (19th September 2013)

• Record Type: Journal Article
• Authors: Zhang, Chen; Chen, Jue; Jia, Xiuzhen; Yu, Shunying; Jiang, Wenhui; Zhang, Ran; Yuan, Aihua; Qian, Yiping; Fan, Juan; Zhang, Mingdao; Fang, Yiru; Xiao, Zeping
• Is Part Of: Asia-Pacific psychiatry. Volume 5:Number 4(2013:Dec.)
• Page Start: 331
• Page End: 335
• Publication Date: 2013-09-19
• Subjects: anorexia nervosa -- association -- estrogen receptor 1 gene -- meta‐analysis -- polymorphism; Psychiatry -- Pacific Area -- Periodicals; 616.890095
• DOI: 10.1111/appy.12100
• Languages: English
• ISSNs: 1758-5864

Abstract

Abstract: Introduction: Estrogen plays essential roles in the regulation of food intake, adiposity, and body weight control. The estrogen alpha receptor, encoded by estrogen receptor 1 gene ( ESR1 ), has been implicated with anorexia nervosa (AN). A previous study indicated that the rs2295193 polymorphism in ESR1 may confer a genetic susceptibility to AN. Methods: In a case‐control study, we assessed 195 AN probands and 93 healthy controls; 99 trios were studied in a family‐based association analysis through genotyping the rs2295193 polymorphism in ESR1 . Additionally, we carried out a meta‐analysis of the combined sample groups. Results: There were no significant differences in the genotype or allele frequencies of the rs2295193 polymorphism between the AN and control groups ( P s > 0.05). In the transmission disequilibrium test (TDT) analyses, there was no evidence for biased transmission of the G allele of rs2295193 polymorphism ( P = 0.32). In female‐only samples, no significant association was observed between the rs2295193 polymorphism and AN in either case‐control or transmission disequilibrium test analyses ( P s > 0.05). The meta‐analysis revealed that no excess of transmission of the G allele in AN families (pooled odds ratio = 1.10, P = 0.79). Discussion: Meta‐analytically combined evidence from the present genotyping and the literature showed that rs2295193 polymorphism in ESR1 is not a major genetic susceptibility factor in AN.