Ectoderm–mesoderm crosstalk in the embryonic limb: The role of fibroblast growth factor signaling. Issue 4 (6th February 2017)

• Record Type: Journal Article
• Authors: Mariani, Francesca V.; Fernandez‐Teran, Marian; Ros, Maria A.
• Other Names: Ornitz David M. guestEditor.; Bellusci Saverio guestEditor.
• Is Part Of: Developmental dynamics. Volume 246:Issue 4(2017)
• Page Start: 208
• Page End: 216
• Publication Date: 2017-02-06
• Subjects: limb development -- FGFs -- AER; Morphogenesis -- Periodicals; Anatomy -- Periodicals; Anatomie -- Périodiques; Biologie du développement -- Périodiques; 571.833
• DOI: 10.1002/dvdy.24480
• Languages: English
• ISSNs: 1058-8388

Abstract

Abstract : In this commentary we focus on the function of FGFs during limb development and morphogenesis. Our goal is to understand, interpret and, when possible, reconcile the interesting findings and conflicting results that remain unexplained. For example, the cell death pattern observed after surgical removal of the AER versus genetic removal of the AER‐Fgfs is strikingly different and the field is at an impasse with regard to an explanation. We also discuss the idea that AER function may involve signaling components in addition to the AER‐FGFs and that signaling from the non‐AER ectoderm may also have a significant contribution. We hope that a re‐evaluation of current studies and a discussion of outstanding questions will motivate new experiments, especially considering the availability of new technologies, that will fuel further progress toward understanding the intricate ectoderm‐to‐mesoderm crosstalk during limb development. Developmental Dynamics 246:208–216, 2017 . © 2016 Wiley Periodicals, Inc. Key Findings: We try to expose, interpret and, when possible, reconcile the discrepant results obtained when investigating the roles of FGF signaling during limb morphogenesis. Our goal is to set the stage for further progress in understanding the intricate roles of Fgf signaling. Considering the availability of new technologies, we propose new experiments that should help in the complete resolution of pending questions.