Urothelial generation and regeneration in development, injury, and cancer. Issue 4 (2nd March 2017)

• Record Type: Journal Article
• Authors: Wang, Caihong; Ross, Whitney Trotter; Mysorekar, Indira U.
• Other Names: Ornitz David M. guestEditor.; Bellusci Saverio guestEditor.
• Is Part Of: Developmental dynamics. Volume 246:Issue 4(2017)
• Page Start: 336
• Page End: 343
• Publication Date: 2017-03-02
• Subjects: bladder -- stem cells -- progenitor cells -- regeneration -- Uropathogenic E. coli; urinary tract infections; retinoic acid; BMP4; Morphogenesis -- Periodicals; Anatomy -- Periodicals; Anatomie -- Périodiques; Biologie du développement -- Périodiques; 571.833
• DOI: 10.1002/dvdy.24487
• Languages: English
• ISSNs: 1058-8388

Abstract

Abstract : Homeostatic maintenance and repair of the urothelium upon injury are required for a functional bladder in both healthy and disease conditions. Understanding the cellular and molecular mechanisms underlying the urothelial regenerative response is key to designing strategies for tissue repair and ultimately treatments for urologic diseases including urinary tract infections, voiding dysfunction, painful bladder syndrome, and bladder cancer. In this article, we review studies on urothelial ontogeny during development and regeneration following various injury modalities. Signaling pathways involved in urothelial regeneration and in urothelial carcinogenesis are also discussed. Developmental Dynamics 246:336–343, 2017 . © 2016 Wiley Periodicals, Inc. Key Findings: In this article, we review studies on urothelial ontogeny during development and regeneration following various injury modalities. Signaling pathways involved in urothelial regeneration and in urothelial carcinogenesis are also discussed.