A facile preparation method for nanosized MOFs as a multifunctional material for cellular imaging and drug delivery. Issue 6 (3rd June 2017)

• Record Type: Journal Article
• Authors: Park, Kyeng Min; Kim, Hyunuk; Murray, James; Koo, Jaehyoung; Kim, Kimoon
• Is Part Of: Supramolecular chemistry. Volume 29:Issue 6(2017)
• Page Start: 441
• Page End: 445
• Publication Date: 2017-06-03
• Subjects: Metal-organic framework -- nanoparticles -- bioimaging -- drug delivery -- endocytosis; Macromolecules -- Periodicals; Supramolecular chemistry -- Periodicals; 547.005
• DOI: 10.1080/10610278.2016.1266359
• Languages: English
• ISSNs: 1061-0278

Abstract

Abstract: Tb-based metal-organic framework nanoparticles (Tb-MOF NPs) with good colloidal stability and stable fluorescence properties in an aqueous solution were prepared by a simple mechanical grinding of Tb-MOF with a biocompatible polymer surfactant (F127). The characteristic fluorescence property of Tb-MOF NPs allowed us to use this nanomaterial as a cell imaging probe. Efficient cellular uptake of Tb-MOF NPs apparently via an energy-dependent endocytosis was observed by confocal laser scanning microscopy. By taking advantage of the porous nature of the Tb-MOF NPs an anticancer drug (doxorubicin) was successfully loaded and delivered to kill cancer cells to demonstrate their usage as a drug delivery vehicle. This simple grinding method afforded a nanosized, multifunctional biomaterial that was used for cell imaging and drug delivery, and it can be extended to other MOFs to widen their applications. Abstract :