Chrysin as an Anti-Cancer Agent Exerts Selective Toxicity by Directly Inhibiting Mitochondrial Complex II and V in CLL B-lymphocytes. (16th March 2017)

• Record Type: Journal Article
• Authors: Salimi, Ahmad; Roudkenar, Mehryar Habibi; Seydi, Enayatollah; Sadeghi, Leila; Mohseni, Alireza; Pirahmadi, Nahal; Pourahmad, Jalal
• Is Part Of: Cancer investigation. Volume 35:Number 3(2017)
• Page Start: 174
• Page End: 186
• Publication Date: 2017-03-16
• Subjects: Chrysin -- mitochondria -- complex II -- CLL -- complex V; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2016.1276187
• Languages: English
• ISSNs: 0735-7907

Abstract

ABSTRACT: We investigated the effect of chrysin on isolated normal and chronic lymphocytic leukemia (CLL) B-lymphocytes and their isolated mitochondria. We report that a selective and significant increase in cytotoxicity, intracellular reactive oxygen species, mitochondrial membrane potential collapse, ADP/ATP ratio, caspase 3 activation and finally apoptosis in chrysin-treated CLL B- lymphocytes. Also we determined that chrysin selectively inhibits complex II and ATPases in cancerous mitochondria. In this study we proved that the ability of chrysin to promote apoptosis in CLL B-lymphocytes performed by selectively targeting of mitochondria. Our findings may provide a potential therapeutic approach for using chrysin to target mitochondria in CLL B-lymphocytes.