Light responsive metal–organic frameworks as controllable CO-releasing cell culture substrates. Issue 3 (11th January 2017)

• Record Type: Journal Article
• Authors: Diring, Stéphane; Carné-Sánchez, Arnau; Zhang, JiCheng; Ikemura, Shuya; Kim, Chiwon; Inaba, Hiroshi; Kitagawa, Susumu; Furukawa, Shuhei
• Is Part Of: Chemical science. Volume 8:Issue 3(2017)
• Page Start: 2381
• Page End: 2386
• Publication Date: 2017-01-11
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6sc04824b
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : Carbon monoxide-releasing metal–organic frameworks are developed for investigating gas biology at the single cell level. Abstract : A new carbon monoxide (CO)-releasing material has been developed by embedding a manganese carbonyl complex, MnBr(bpydc)(CO)3 (bpydc = 5, 5′-dicarboxylate-2, 2′-bipyridine) into a highly robust Zr(iv )-based metal–organic framework (MOF). Efficient and controllable CO-release was achieved under exposure to low intensity visible light. Size-controllable nanocrystals of the photoactive MOF were obtained and their CO-releasing properties were correlated with their crystal sizes. The photoactive crystals were processed into cellular substrates with a biocompatible polymer matrix, and the light-induced delivery of CO and its subsequent cellular uptake were monitored using a fluorescent CO-probe. The results discussed here demonstrate a new opportunity to use MOFs as macromolecular scaffolds towards CO-releasing materials and the advantage of MOFs for high CO payloads, which is essential in future therapeutic applications.