Post-transcriptional regulation of cytokine and growth factor signaling in cancer. (February 2017)

• Record Type: Journal Article
• Authors: Vlasova-St. Louis, Irina; Bohjanen, Paul R.
• Is Part Of: Cytokine & growth factor reviews. Volume 33(2017)
• Page Start: 83
• Page End: 93
• Publication Date: 2017-02
• Subjects: 3′UTR untranslated region -- ARE AU-rich element -- GRE GU-rich element -- RNA-BP RNA-binding protein -- ARE-PB ARE-binding protein -- GRE-BP GRE-binding protein -- ELAVL1 embryonic lethal abnormal vision-like 1 (Hu antigen R) -- ZFP36 zinc finger protein 36 -- TTP tristetraprolin -- CELF1 CUGBP-ELAV-like family member 1 -- HNRNPD heterogeneous nuclear ribonucleoprotein D -- KSRP KH-type splicing regulatory protein -- GAPDH glyceraldehyde 3-phosphate dehydrogenase -- VEGF vascular endothelial growth factor -- VEGFR vascular endothelial growth factor receptor -- GF growth factor -- GFRs growth factor receptors -- uPA urokinase plasminogen activator -- CXCL8 C-X-C motif ligand 8 IL Interleukin -- PKC protein kinase C -- MAPK mitogen-activated protein kinase -- mTOR mammalian target of rapamycin -- MMP9 matrix metalloproteinase 9 -- NFkB nuclear factor kappa B -- STAT signal transducer and activator of transcription -- FGFs fibroblast growth factors -- EGF epidermal growth factor -- TFNα tumor necrosis factor-alpha -- ICAM intercellular adhesion molecule -- VCAM vascular cell adhesion molecule -- CSF1 colony-stimulating factor one -- DM1 myotonic dystrophy type 1 -- EMT epithelial-to-mesenchymal transitions -- PIA/RICTOR RPTOR independent companion of MTOR complex 2; Cytokine and growth factor signaling -- Post-transcriptional gene regulation -- ARE -- GRE -- mRNA stability -- Cancer; Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2016.11.004
• Languages: English
• ISSNs: 1359-6101

Abstract

Graphical abstract: Highlights: Examination of published scientific data in the field of post-transcriptional regulation of cytokine and growth-factor signaling. AREs and GREs regulate mRNA turnover to coordinate cytokine and growth factor expression. Three RNA-binding proteins that competitively regulate mRNA stability through ARE and GRE are discussed. Dysregulation of mRNA degradation contributes to the development and progression of cancer. Abstract: Cytokines and growth factors regulate cell proliferation, differentiation, migration and apoptosis, and play important roles in coordinating growth signal responses during development. The expression of cytokine genes and the signals transmitted through cytokine receptors are tightly regulated at several levels, including transcriptional and post-transcriptional levels. A majority of cytokine mRNAs, including growth factor transcripts, contain AU-rich elements (AREs) in their 3′ untranslated regions that control gene expression by regulating mRNA degradation and changing translational rates. In addition, numerous proteins involved in transmitting signals downstream of cytokine receptors are regulated at the level of mRNA degradation by GU-rich elements (GREs) found in their 3′ untranslated regions. Abnormal stabilization and overexpression of ARE or GRE-containing transcripts had been observed in many malignancies, which is a consequence of the malfunction of RNA-binding proteins. In this review, we briefly summarize the role of AREs and GREs in regulating mRNA turnover to coordinate cytokine and growth factor expression, and we describe how dysregulation of mRNA degradation mechanisms contributes to the development and progression of cancer.