Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide. Issue 7 (18th December 2014)

• Record Type: Journal Article
• Authors: Usui, Kenji; Okada, Arisa; Kobayashi, Keita; Sugimoto, Naoki
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 7(2015)
• Page Start: 2022
• Page End: 2025
• Publication Date: 2014-12-18
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c4ob02535k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an enzyme-responsive functionality, depending on the protease activity was constructed. Abstract : We constructed a regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an on-to-off switching functionality, depending on the protease activity. This study introduces the new concept of a simple and powerful system for regulating quadruplex-related important biological events.