Diastereoselective synthesis of trifluoromethylated 1, 3-dioxanes by intramolecular oxa-Michael reaction. Issue 2 (29th November 2016)

• Record Type: Journal Article
• Authors: Becerra-Figueroa, Liliana; Brun, Elodie; Mathieson, Michael; Farrugia, Louis J.; Wilson, Claire; Prunet, Joëlle; Gamba-Sánchez, Diego
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 2(2017)
• Page Start: 301
• Page End: 305
• Publication Date: 2016-11-29
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob02333a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A rapid and simple method to access trifluoromethylated 1, 3-dioxanes by a sequence of addition/oxa-Michael reaction has been developed; the reaction proceeds smoothly with excellent stereoselectivity. Abstract : A highly diastereoselective synthesis of trifluoromethylated 1, 3-dioxanes is described. The reaction proceeds by an addition/oxa-Michael sequence and works efficiently under mild reaction conditions, with a good substrate scope and acceptable to good yields.