Substrate selective amide coupling driven by encapsulation of a coupling agent within a self-assembled hexameric capsule. Issue 9 (15th December 2014)

• Record Type: Journal Article
• Authors: Giust, Sonia; La Sorella, Giorgio; Sperni, Laura; Strukul, Giorgio; Scarso, Alessandro
• Is Part Of: Chemical communications. Volume 51:Issue 9(2015)
• Page Start: 1658
• Page End: 1661
• Publication Date: 2014-12-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c4cc08833f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Encapsulation of a cationic carbodiimide condensing agent within a self-assembled hexameric capsule made of resorcin[4]arene units provides a nano-environment that efficiently steers the substrate selectivity in the amide synthesis reaction between carboxylic acids and primary amines. Abstract : Encapsulation of a cationic carbodiimide condensing agent within a self-assembled hexameric capsule made of resorcin[4]arene units provides a nano-environment that efficiently steers the substrate selectivity in the amide synthesis reaction between carboxylic acids and primary amines. While in solution pairs of acids react similarly with a given amine, in the presence of the capsule the formation of the shorter amide is greatly favored.