A fast-responsive mitochondria-targeted fluorescent probe detecting endogenous hypochlorite in living RAW 264.7 cells and nude mouse. Issue 8 (9th December 2014)

• Record Type: Journal Article
• Authors: Xiao, Hongde; Xin, Kai; Dou, Haifang; Yin, Gui; Quan, Yiwu; Wang, Ruiyong
• Is Part Of: Chemical communications. Volume 51:Issue 8(2015)
• Page Start: 1442
• Page End: 1445
• Publication Date: 2014-12-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c4cc07411d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A very fast-responsive fluorescent probe for imaging mitochondrial ClO − was prepared. The probe was successfully applied in the imaging of endogenous ClO − in the mitochondria of RAW 264.7 cells and living nude mouse. Abstract : A very fast-responsive fluorescent probe PZ–Py for imaging mitochondrial HClO/ClO −, with a relatively long emission wavelength, was prepared. The limit of detection was evaluated to be 17.9 nM. Moreover, the probe PZ–Py was successfully applied in the imaging of endogenous HClO/ClO − in the mitochondria of RAW 264.7 cells and living nude mouse.