Transition metal free intramolecular selective oxidative C(sp3)–N coupling: synthesis of N-aryl-isoindolinones from 2-alkylbenzamides12. Issue 7 (9th December 2014)

• Record Type: Journal Article
• Authors: Verma, Ajay; Patel, Saket; Meenakshi, ; Kumar, Amit; Yadav, Abhimanyu; Kumar, Shailesh; Jana, Sadhan; Sharma, Shubham; Prasad, Ch. Durga; Kumar, Sangit
• Is Part Of: Chemical communications. Volume 51:Issue 7(2015)
• Page Start: 1371
• Page End: 1374
• Publication Date: 2014-12-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c4cc08717h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A transition metal-free intramolecular selective oxidative coupling reaction of C(sp 3 )–H and N–H bonds has been presented utilizing iodine, potassium carbonate and di- tert -butyl peroxide in acetonitrile at 110–140 °C. Abstract : A synthetic method has been developed for the preparation of biologically important isoindolinones including indoprofen and DWP205190 drugs from 2-alkylbenzamide substrates by transition metal-free intramolecular selective oxidative coupling of C(sp 3 )–H and N–H bonds utilizing iodine, potassium carbonate and di- tert -butyl peroxide in acetonitrile at 110–140 °C.