An enzyme-free and amplified colorimetric detection strategy via target–aptamer binding triggered catalyzed hairpin assembly. Issue 5 (1st December 2014)

• Record Type: Journal Article
• Authors: Quan, Ke; Huang, Jin; Yang, Xiaohai; Yang, Yanjing; Ying, Le; Wang, He; He, Yong; Wang, Kemin
• Is Part Of: Chemical communications. Volume 51:Issue 5(2015)
• Page Start: 937
• Page End: 940
• Publication Date: 2014-12-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c4cc08488h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Here we introduce an enzyme-free and colorimetric detection strategy for adenosine. The approach is based on that the adenosine triggers catalyzed hairpin assembly, which induces gold nanoparticles aggregation via crosslinking. Abstract : Here we introduce an enzyme-free and colorimetric detection strategy for small molecule adenosine. The approach is based on the adenosine–aptamer binding triggered liberation of an initiator strand that consecutively catalyzes DNA hairpins hybridized from singles to couples. These couples induce gold nanoparticles assembled via crosslinking, which could be visualized by a color change.