Catalytic highly enantioselective transfer hydrogenation of β-trifluoromethyl nitroalkenes. An easy and general entry to optically active β-trifluoromethyl amines. Issue 4 (21st November 2014)

• Record Type: Journal Article
• Authors: Martinelli, Emilie; Vicini, Anna Chiara; Mancinelli, Michele; Mazzanti, Andrea; Zani, Paolo; Bernardi, Luca; Fochi, Mariafrancesca
• Is Part Of: Chemical communications. Volume 51:Issue 4(2015)
• Page Start: 658
• Page End: 660
• Publication Date: 2014-11-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c4cc07801b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An easy, general and highly enantioselective entry to optically active β-trifluoromethyl amines via organocatalytic transfer hydrogenation of β-trifluoromethyl nitroalkenes is presented. Abstract : In the presence of a thiourea catalyst, β-CF3 nitroalkenes react with Hantzsch esters in a highly enantioselective fashion, giving a broad range of β-CF3 amine precursors with a tertiary stereocentre at the β-position. This reaction represents the first general catalytic enantioselective approach to this important class of β-CF3 amines.