One-pot cascade synthesis of N-methoxyisoquinolinediones via Rh(iii)-catalyzed carbenoid insertion C–H activation/cyclization. Issue 4 (21st November 2014)

• Record Type: Journal Article
• Authors: Shi, Jingjing; Zhou, Jie; Yan, Yunnan; Jia, Jinlong; Liu, Xuelei; Song, Huacan; Xu, H. Eric; Yi, Wei
• Is Part Of: Chemical communications. Volume 51:Issue 4(2015)
• Page Start: 668
• Page End: 671
• Publication Date: 2014-11-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c4cc08407a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A mild and efficient method for one-pot synthesis of N -methoxyisoquinolinediones via Rh(iii )-catalyzed carbenoid insertion C–H activation/cyclization has been developed. Abstract : Here a new, mild and versatile method for one-pot cascade synthesis of diverse N -methoxyisoquinolinediones via Rh(iii )-catalyzed regioselective carbenoid insertion C–H activation/cyclization of N -methoxybenzamides with α-diazotized Meldrum's acid has been achieved. Extension of the developed Rh(iii ) catalysis for building new analogs of the marketed drug Edaravone has also been demonstrated.