A nickel-mediated oxidative α-C(sp3)–H functionalization of amides with allylic alcohols terminated by radical 1, 2-aryl migration. Issue 4 (25th November 2014)

• Record Type: Journal Article
• Authors: Song, Ren-Jie; Tu, Yong-Qiang; Zhu, Dao-Yong; Zhang, Fu-Min; Wang, Shao-Hua
• Is Part Of: Chemical communications. Volume 51:Issue 4(2015)
• Page Start: 749
• Page End: 752
• Publication Date: 2014-11-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c4cc08797f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A Ni-mediated oxidative C(sp 3 )–H functionalization of N, N -substituted amides with α, α-diaryl allylic alcohols through a radical 1, 2-aryl migration process has been developed. This process features a broad substrate scope and excellent functional group tolerance. Abstract : A Ni-mediated oxidative C(sp 3 )–H functionalization of N, N -substituted amides with α, α-diaryl allylic alcohols through a radical 1, 2-aryl migration process has been developed. This process features a broad substrate scope and excellent functional group tolerance. Notably, γ-amino ketones containing an all-carbon quaternary center were synthesized under these conditions in moderate to good yields.