Tumor-targeted supramolecular nanoparticles self-assembled from a ruthenium-β-cyclodextrin complex and an adamantane-functionalized peptide. Issue 5 (5th December 2016)

• Record Type: Journal Article
• Authors: Xue, Shan-Shan; Tan, Cai-Ping; Chen, Mu-He; Cao, Jian-Jun; Zhang, Dong-Yang; Ye, Rui-Rong; Ji, Liang-Nian; Mao, Zong-Wan
• Is Part Of: Chemical communications. Volume 53:Issue 5(2017)
• Page Start: 842
• Page End: 845
• Publication Date: 2016-12-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc08296c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A supramolecular strategy was presented to form water-soluable Ru(ii ) nanoparticles. The particles can induce cell death in integrin αv β3 -rich tumor cells with high selectivity. Abstract : We report here a supramolecular strategy to assemble a cyclodextrin-functionalized anticancer Ru(ii ) complex with an adamantane-appended tumor-targeting peptide into discrete and stable phosphorescent nanostructures that can induce cell death in integrin αv β3 -rich tumor cells with high selectivity. This strategy presents new opportunities for the construction of tumor-targeting metallo-anticancer therapeutics.