Au(iii) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists. Issue 1 (18th November 2016)

• Record Type: Journal Article
• Authors: Spell, Sarah R.; Mangrum, John B.; Peterson, Erica J.; Fabris, Daniele; Ptak, Roger; Farrell, Nicholas P.
• Is Part Of: Chemical communications. Volume 53:Issue 1(2017)
• Page Start: 91
• Page End: 94
• Publication Date: 2016-11-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc07970a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Interaction of [Au(dien)(9-EtGua)] 3+ abrogates NC binding to cognate SL2 sequence by Zn 2+ displacement by Au. Abstract : The HIV nucleocapsid NCp7–SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN4 compound where the N-heterocycle serves the dual purposes of a template for "non-covalent" molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent "fixation" by Au–Cys bond formation providing a chemotype for a new distinct class of nucleocapsid–nucleic acid antagonist.