Evaluation of risk factors for extrahepatic cholangiocarcinoma: ABO blood group, hepatitis B virus and their synergism. Issue 8 (8th May 2013)

• Record Type: Journal Article
• Authors: Zhou, Yu; Zhou, Quanbo; Lin, Qing; Chen, Ruiwan; Gong, Yuanfeng; Liu, Yimin; Yu, Min; Zeng, Bing; Li, Kaiwen; Chen, Rufu; Li, Zhihua
• Is Part Of: International journal of cancer. Volume 133:Issue 8(2013:Oct. 15)
• Page Start: 1867
• Page End: 1875
• Publication Date: 2013-05-08
• Subjects: bile duct cancer -- epidemiology -- hepatitis -- ABO blood group; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.28196
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract : Little is known about the role of association between ABO blood group and development of extrahepatic cholangiocarcinoma (ECC) through effects on hepatitis B viral (HBV) infection. Our aim was to address this question using a matched case–control study in Southern China.We prospectively analyzed 239 ECC patients, and 478 age‐ and sex‐matched controls in Sun Yat‐sen Memorial Hospital of Sun Yat‐sen University from 1999 to 2011. Information on ABO blood group, HBV infection and other clinicopathologic factors was collected. Adjusted odds ratios (AORs) and the corresponding 95% confidence intervals (CIs) were computed from unconditional logistic regression models, adjusted for major confounding factors. The estimated AORs were as follows: A blood group, 1.784; HBsAg+/HbcAb+, 1.848 and HBsAg−/HbcAb+, 1.501. The A blood type had a significant effect on modifying the risk of ECC among subjects with HBsAg+/HbcAb+ (AOR 3.795, 95% CI 1.427–10.090). ECC patients with A blood group were more common in younger subjects, and a lower proportion of serum CA‐125 and CA19‐9 elevation in patients with blood type A was found. Our study suggests an association between A blood type, HBV infection and ECC risk, and a synergism between A blood type and HBV infection in the development of ECC. Abstract : What's new? Hepatitis B virus (HBV) infection is a suspected risk factor for extrahepatic cholangiocarcinoma (ECC), though how it gives rise to malignant disease of the bile ducts situated outside the liver is unclear. Here, a significant association was found for HBV infection, A blood type, and ECC risk in the Han Chinese ethnic group of Southern China. Compared with non‐A blood group ECC patients, type A ECC patients tended to be younger and had lower CA‐125 and CA19‐9 levels. The study is the first to confirm an association between A blood group, HBV, and ECC risk.