Synthesis and Antimalarial Bioassay of Quinine – Peptide Conjugates. (19th September 2013)

• Record Type: Journal Article
• Authors: Panda, Siva S.; Ibrahim, Mohamed A.; Küçükbay, Hasan; Meyers, Marvin J.; Sverdrup, Francis M.; El‐Feky, Said A.; Katritzky, Alan R.
• Is Part Of: Chemical biology & drug design. Volume 82:Number 4(2013:Oct.)
• Page Start: 361
• Page End: 366
• Publication Date: 2013-09-19
• Subjects: amino acid -- chemical biology -- drug design -- peptide; Drugs -- Design -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; 615.19005
• DOI: 10.1111/cbdd.12134
• Languages: English
• ISSNs: 1747-0277

Abstract

Abstract : Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52–95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100 nm, similar to quinine. Abstract : A series of quinine‐peptide conjugates were by coupling amino acids and peptides varying polarity with quinine in good yields and the majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100 nm, similar to quinine.