The direct α-C(sp3)–H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing12. Issue 2 (14th November 2014)

• Record Type: Journal Article
• Authors: Brzozowski, Martin; Forni, Jose A.; Paul Savage, G.; Polyzos, Anastasios
• Is Part Of: Chemical communications. Volume 51:Issue 2(2015)
• Page Start: 334
• Page End: 337
• Publication Date: 2014-11-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c4cc07913b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An efficient nitro-Mannich type direct α-C(sp 3 )–H functionalisation of N -aryl-1, 2, 3, 4-tetrahydroisoquinolines catalysed by simple iron salts in combination with O2 as the terminal oxidant is described. Abstract : An efficient nitro-Mannich type direct α-C(sp 3 )–H functionalisation of N -aryl-1, 2, 3, 4-tetrahydroisoquinolines catalysed by simple iron salts in combination with O2 as the terminal oxidant is described. The use of a Teflon AF-2400 membrane Tube-in-Tube reactor under continuous flow conditions allowed for considerable process intensification to be achieved relative to previous batch methods.